Resident Population in Greenville County, SC was 558.03600 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Greenville County, SC reached a record high of 558.03600 in January of 2023 and a record low of 240.77400 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Greenville County, SC - last updated from the United States Federal Reserve on May of 2024.